Converging and Correlative Technologies for Optical Nanoscopy

NBIC, THE CONVERGING TECHNOLOGIES

Correlative nonlinear optical microscopy and infrared nanoscopy reveals collagen degradation in altered parchments

This paper presents the correlative imaging of collagen denaturation by nonlinear optical microscopy (NLO) and nanoscale infrared (IR) spectroscopy to obtain morphological and chemical information at different length scales. Such multiscale correlated measurements are applied to the investigation of ancient parchments, which are mainly composed of dermal fibrillar collagen. The main issue is to...

nbic, the converging technologies

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Emerging optical nanoscopy techniques

To face the challenges of modern health care, new imaging techniques with subcellular resolution or detection over wide fields are required. Far field optical nanoscopy presents many new solutions, providing high resolution or detection at high speed. We present a new classification scheme to help appreciate the growing number of optical nanoscopy techniques. We underline an important distincti...

Far - Field Optical Nanoscopy

37. E. Evans, Annu. Rev. Biophys. Biomol. Struct. 30, 105 (2001). 38. G. I. Bell, Science 200, 618 (1978). 39. For adhesive interactions important in soft tissues and organs of eukaryotic cell systems, the average times toff° reported for spontaneous dissociation of ligand/receptor bonds range from a fraction of a second to 100 s or more. 40. Because of thermal activation, the appropriate unit ...